Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer
Satoshi Nakamura, Daisuke Shibahara, Kentaro Tanaka, Yasuyuki Kishikawa, Mikiko Hashisako, Keita Nakatomi, Noriaki Nakagaki, Mikihiro Kohno, Koichi Azuma, Ritsu Ibusuki, Kohei Otsubo, Yasuto Yoneshima, Eiji Iwama, Yoshinao Oda, Isamu Okamoto
The paper uses spatial transcriptomics to analyze pre- and post-treatment tumor samples, identifying fibroblast activation and tumor heterogeneity as factors in early EGFR-TKI resistance.
bioRxiv · Feb 10, 2025 · PreprintCancer Biology