Author

Kohei Otsubo

Kyushu UniversityORCID 0000-0002-9476-8840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Daisuke ShibaharaiD· 2 shared Eiji IwamaiD· 2 shared Isamu OkamotoiD· 2 shared Kentaro TanakaiD· 2 shared Aiko Hirayama· 1 shared Atsushi Shimauchi· 1 shared Hiroe Shuto· 1 shared Kazuya TsubouchiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Daisuke ShibaharaORCID

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2 papers

Recent·Most cited

Inflammatory signaling drives SQSTM1-dependent suppression of interferon-γ-induced MHC class I

Sho Yamashita, Hiroe Shuto, Aiko Hirayama, Atsushi Shimauchi, Takahiro Utsumi, Toshifumi Ninomiya, Kazuya Tsubouchi, Kohei Otsubo, Daisuke Shibahara, Eiji Iwama, Isamu Okamoto, Kentaro Tanaka

This study shows that IL-1β suppresses IFN-γ-induced MHC-I surface expression in NSCLC cells through SQSTM1-dependent autophagy, revealing a post-transcriptional regulatory mechanism.

bioRxiv · Oct 27, 2026 · PreprintImmunology

Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer

Satoshi Nakamura, Daisuke Shibahara, Kentaro Tanaka, Yasuyuki Kishikawa, Mikiko Hashisako, Keita Nakatomi, Noriaki Nakagaki, Mikihiro Kohno, Koichi Azuma, Ritsu Ibusuki, Kohei Otsubo, Yasuto Yoneshima, Eiji Iwama, Yoshinao Oda, Isamu Okamoto

The paper uses spatial transcriptomics to analyze pre- and post-treatment tumor samples, identifying fibroblast activation and tumor heterogeneity as factors in early EGFR-TKI resistance.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology