Isamu Okamoto

Inflammatory signaling drives SQSTM1-dependent suppression of interferon-γ-induced MHC class I

This study shows that IL-1β suppresses IFN-γ-induced MHC-I surface expression in NSCLC cells through SQSTM1-dependent autophagy, revealing a post-transcriptional regulatory mechanism.

Trajectory inference of epithelial-centered neighborhood profiles reconstructs a pseudo-temporal continuum in idiopathic pulmonary fibrosis

The paper reconstructs a pseudo-temporal continuum of fibrotic remodeling in IPF by analyzing epithelial-centered neighborhood profiles across spatially heterogeneous lung tissue.

Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer

The paper uses spatial transcriptomics to analyze pre- and post-treatment tumor samples, identifying fibroblast activation and tumor heterogeneity as factors in early EGFR-TKI resistance.