Robust reprogramming of glia into neurons by inhibition of Notch signaling and NFI factors in adult mammalian retina.
Nguyet Le, Trieu-Duc Vu, Isabella Palazzo, Ritvik Pulya, Yehna Kim, Seth Blackshaw, Thanh V. Hoang
This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.
bioRxiv · Oct 29, 2023 · PreprintNeuroscience