Nguyet Le

This study shows that viral-mediated Oct4 overexpression and Notch inhibition together induce neurogenic competence in mammalian Muller glia, enabling transdifferentiation into bipolar neurons.

This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.

This study shows that GFAP promoter-driven AAV constructs in adult mouse retina show insert-dependent expression in non-glial cells without evidence of glia-to-neuron conversion.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

The paper investigates the hypoxia-dependent regulation of ndrg1-4 genes in zebrafish embryos, showing ndrg1a is highly upregulated under prolonged anoxia and expressed in new tissues.