Isabella Palazzo

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

This study shows cigarette smoke and aging induce degenerative heterogeneity in RPE cells through distinct epigenetic changes, with young RPE showing compensatory responses not seen in aged RPE.

This study shows that viral-mediated Oct4 overexpression and Notch inhibition together induce neurogenic competence in mammalian Muller glia, enabling transdifferentiation into bipolar neurons.

The paper compares gene regulatory networks in zebrafish retinal regeneration and development after different neuronal subtype losses, finding both similarities and differences.

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.

The paper investigates how microglia depletion affects Muller glia-derived progenitor cell formation in chick retinas using scRNA-seq, identifying key signaling pathways involved.

The paper investigates how different cytokines, growth factors, and damage paradigms affect NFkB signaling in mouse retinal Muller glia, showing activation varies with microglial involvement.

This study shows that NFkB signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina by promoting immune cell accumulation and inhibiting neurogenic potential.

This study investigates MDK's role in retinal development and regeneration in chick and mouse, showing its impact on neuronal survival, glial reactivity, and Müller glia-derived progenitor cell formation.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

This study shows that NF-κB signaling suppresses Muller glia reprogramming into progenitor cells in the chick retina, with microglia modulating this effect.