Thanh V. Hoang

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

AAV-mediated regeneration of neurons in injury-induced and inherited retinal degeneration

This study shows that AAV-delivered Neurog2-9SA converts Muller glia into retinal neurons in degenerative models, integrating into circuits and exhibiting neuronal properties.

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

Cigarette smoke and biological age induce degenerative heterogeneity in retinalpigment epithelium

This study shows cigarette smoke and aging induce degenerative heterogeneity in RPE cells through distinct epigenetic changes, with young RPE showing compensatory responses not seen in aged RPE.

Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia.

This study shows that viral-mediated Oct4 overexpression and Notch inhibition together induce neurogenic competence in mammalian Muller glia, enabling transdifferentiation into bipolar neurons.

miR-26 deficiency causes alterations in lens transcriptome and results in adult-onset cataract

The paper investigates the role of miR-26 in lens development and finds that its deficiency leads to adult-onset cataract through transcriptome alterations.

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.

The paper compares gene regulatory networks in zebrafish retinal regeneration and development after different neuronal subtype losses, finding both similarities and differences.

Molecular regulation of retinal regeneration is context specific

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

Robust reprogramming of glia into neurons by inhibition of Notch signaling and NFI factors in adult mammalian retina.

This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.

Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

This study identifies Pantr2 as a trans-acting lncRNA that regulates gene expression and chromatin accessibility, affecting neural progenitor differentiation through Notch and Wnt signaling disruption.

Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

This study shows that GFAP promoter-driven AAV constructs in adult mouse retina show insert-dependent expression in non-glial cells without evidence of glia-to-neuron conversion.

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

NFkB-signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina

This study shows that NFkB signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina by promoting immune cell accumulation and inhibiting neurogenic potential.

Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk.

The paper identifies cell-class-specific cis-regulatory elements in human retina and organoids, showing their correlation and function in development and disease.

Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the avian retina

This study investigates the role of fatty acid-binding proteins (FABPs) and fatty acid synthase (FASN) in glial reactivity and Müller glia-derived progenitor cell formation in the chick retina using scRNA-seq.

Gene regulatory networks controlling temporal patterning, neurogenesis and cell fate specification in the mammalian retina.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

Ptbp1 deletion does not induce glia-to-neuron conversion in adult mouse retina and brain.

This study shows that deleting Ptbp1 in adult retinal Muller glia and brain astrocytes does not convert glia into neurons, using genetic lineage tracing, scRNA-Seq, and electrophysiology.

Control of neurogenic competence in mammalian hypothalamic tanycytes.

This study identifies NFI factors as repressors of tanycyte-derived neurogenesis and shows their disruption promotes proliferation and neurogenesis in the hypothalamus.

Transcriptomic profiling of human orbital fat and differentiating orbital fibroblasts

The paper uses transcriptomic analysis to compare gene expression in control and TAO patients' orbital fat and differentiating orbital fibroblasts, identifying IGF-1R and Wnt signaling pathway differences.

Cannabinoid signaling promotes the reprogramming of Muller glia into proliferating progenitor cells.

This study investigates the role of the endocannabinoid system in reprogramming Muller glia into progenitor cells in the retina, showing that eCB signaling promotes this process while suppressing NFkB activity in mouse Muller glia.

Midkine in chick and mouse retinas: neuroprotection, glial reactivity and the formation of Müller glia-derived progenitor cells

This study investigates MDK's role in retinal development and regeneration in chick and mouse, showing its impact on neuronal survival, glial reactivity, and Müller glia-derived progenitor cell formation.

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

NF-κB signaling regulates the formation of proliferating Muller glia-derived progenitor cells in the avian retina.

This study shows that NF-κB signaling suppresses Muller glia reprogramming into progenitor cells in the chick retina, with microglia modulating this effect.

Tanycyte-independent control of hypothalamic leptin signaling

This study investigates tanycytic leptin receptor expression and function in mice, finding no detectable LepR in tanycytes and no effect of their deletion on hypothalamic leptin signaling.

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development.

This study uses scRNA-Seq to analyze human and mouse retinal development, identifying conserved and species-specific gene expression patterns and a novel role for ATOH7 in photoreceptor specification.

A widespread decrease of chromatin accessibility in age-related macular degeneration

This study identifies global decreases in chromatin accessibility in AMD patients, linking epigenetic changes to disease progression and suggesting HDAC11 as a potential therapeutic target.