Repurposing the TIGR-Tas system for programmable transcription activation
Yetong Sang, Li Xu, Nga Man Wong, Yongfei Chang, Zhenkun Cai, Zehua Bao
This paper repurposes the TIGR-Tas system for gene activation, achieving robust and specific transcriptional activation of human genes with a compact system potentially independent of PAMs.
bioRxiv · Aug 5, 2026 · PreprintGenetics