Jie Zhu

Paired activity learning supports systematic identification of mutant-selective EGFR inhibitors

The paper develops a computational-experimental framework to identify mutant-selective EGFR inhibitors by leveraging paired activity measurements and structural analysis.

Isoleucine and asparagine influence the growth of staphylococcal strains in atopic dermatitis

The paper investigates how isoleucine and asparagine affect the growth of staphylococcal strains in atopic dermatitis, finding they promote S. aureus growth and inhibit S. hominis growth.

Multiplex genome engineering in yeast using the TIGR-Tas system

This paper demonstrates the use of TIGR-Tas system for multiplex genome engineering in yeast, achieving targeted DNA breaks and gene modifications without PAM requirements.

Domain-adversarial learning predicts clinically actionable drug combination synergy in leukemia patients using bulk transcriptomics data

This paper develops a domain-adversarial neural network to predict drug combination synergy in leukemia patients using bulk transcriptomics data, showing improved accuracy over existing methods.

TRIM21 is a molecular rheostat for influenza A virus replication

This study shows TRIM21 acts as a molecular rheostat regulating influenza A virus replication by modulating ubiquitination and innate immune signaling, with PRKDC as a compensatory antiviral factor when TRIM21 is absent.

Isolation of the first cultured representative from a deep-branching phylum in serpentinite-hosted ecosystems

The paper isolates the first cultured strain of the deep-branching phylum Candisdatus Bipolaricaulota from a serpentinite-hosted ecosystem and describes its hydrocarbon metabolism and morphology.

Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

This study shows that transplanting exogenous mitochondria improves myocardial function and survival after cardiac arrest by enhancing mitochondrial activity and reducing oxidative stress.

The appressorium of Magnaporthe oryzae remains mitotically active during post-penetration hyphal growth in rice cells

The paper uses time-lapse imaging to show that appressoria remain mitotically active after penetrating rice cells, with unique nuclear dynamics during hyphal growth.