Author

Zhenkun Cai

Zhejiang UniversityORCID 0000-0002-0199-4866Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:CRISPR screen· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Organism:yeast· 1

Frequent Co-Authors

Li XuiD· 2 shared Nga Man Wong· 2 shared Yetong Sang· 2 shared Yongfei Chang· 2 shared Zehua BaoiD· 2 shared Chang-Ting Chen· 1 shared Jie Zhu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Li XuORCID

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2 papers

Recent·Most cited

Repurposing the TIGR-Tas system for programmable transcription activation

Yetong Sang, Li Xu, Nga Man Wong, Yongfei Chang, Zhenkun Cai, Zehua Bao

This paper repurposes the TIGR-Tas system for gene activation, achieving robust and specific transcriptional activation of human genes with a compact system potentially independent of PAMs.

bioRxiv · Aug 5, 2026 · PreprintGenetics

Multiplex genome engineering in yeast using the TIGR-Tas system

Zhenkun Cai, Yetong Sang, Li Xu, Yongfei Chang, Nga Man Wong, Jie Zhu, Chang-Ting Chen, Zehua Bao

This paper demonstrates the use of TIGR-Tas system for multiplex genome engineering in yeast, achieving targeted DNA breaks and gene modifications without PAM requirements.

bioRxiv · Jul 31, 2026 · PreprintSynthetic Biology