Author

Yi-Chun Shih

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

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Assay:electronic health records· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Michael JanečekiD· 4 shared Rui T. PeixotoiD· 4 shared Lars Nelson· 3 shared Michael Matarazzo· 3 shared Andrew D’Agostino· 2 shared Kyle D. KetchesiniD· 1 shared Megan S. Perez· 1 shared Susana da SilvaiD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersNeuroscience

Michael JanečekORCID

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Author profile →

4 papers

Recent·Most cited

Striatal output regulates the postnatal maturation of cortical circuits

Michael Janeček, Tara Deemyad, Yi-Chun Shih, Vicente Valle, Andrew D’Agostino, Michael Matarazzo, Megan S. Perez, Kyle D. Ketchesin, Susana da Silva, Rui T. Peixoto

This study shows that striatal output during early postnatal development affects the activity and maturation of the dorsomedial prefrontal cortex circuits in mice.

Cell Reports · Aug 23, 2025Peer-reviewedNeuroscience

Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B-/- Mice

Yi-Chun Shih, Lars Nelson, Michael Janeček, Michael Matarazzo, Andrew D’Agostino, Rui T. Peixoto

This study identifies early dysfunction in ACC PV interneurons and HCN channelopathy in Shank3B-/- mice, leading to circuit reorganization and impaired inhibition.

Molecular Psychiatry · Jul 19, 2025Peer-reviewedNeuroscience

Late onset of striatal projection neuron hyperexcitability in Fmr1-/y mice

Lars Nelson, Michael Janeček, Michael Matarazzo, Yi-Chun Shih, Rui T. Peixoto

This study shows that striatal projection neurons in Fmr1 knockout mice develop normally but become hyperexcitable by postnatal day 60, with limited response to aripiprazole treatment.

bioRxiv · Jun 21, 2025 · PreprintNeuroscience

Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B-/- mice

Yi-Chun Shih, Lars Nelson, Michael Janeček, Rui T. Peixoto

This study investigates synaptic deficits in cortical PV interneurons of Shank3B-/- mice, finding reduced mEPSC frequency in adulthood but not early development, and region-specific differences.

bioRxiv · Nov 23, 2023 · PreprintNeuroscience