Rui T. Peixoto

Structural dynamics insights into principles underlying the fitness of new broadly potent AAVs

The paper develops a new AAV engineering workflow, scAAVengr-Hunt, to create potent vectors and identifies a structural mechanism underlying their broad species and tissue potency.

Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids

This paper introduces an electroporation-based method for efficient gene delivery in human retinal organoids, combined with two-photon microscopy for high-resolution imaging.

Striatal output regulates the postnatal maturation of cortical circuits

This study shows that striatal output during early postnatal development affects the activity and maturation of the dorsomedial prefrontal cortex circuits in mice.

Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B-/- Mice

This study identifies early dysfunction in ACC PV interneurons and HCN channelopathy in Shank3B-/- mice, leading to circuit reorganization and impaired inhibition.

Late onset of striatal projection neuron hyperexcitability in Fmr1-/y mice

This study shows that striatal projection neurons in Fmr1 knockout mice develop normally but become hyperexcitable by postnatal day 60, with limited response to aripiprazole treatment.

Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B-/- mice

This study investigates synaptic deficits in cortical PV interneurons of Shank3B-/- mice, finding reduced mEPSC frequency in adulthood but not early development, and region-specific differences.

Integrated tapered fibertrode for simultaneous control and readout of neural activity over small brain volumes with reduced light-induced artefacts

This paper introduces an integrated fibertrode that enables simultaneous optogenetic control and electrical recording of neural activity in small brain volumes with reduced photoelectric artifacts.

Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production

This study shows PRDM16 regulates MGE progenitor proliferation and GABAergic interneuron production by repressing differentiation genes.