Michael Janeček

Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids

This paper introduces an electroporation-based method for efficient gene delivery in human retinal organoids, combined with two-photon microscopy for high-resolution imaging.

Striatal output regulates the postnatal maturation of cortical circuits

This study shows that striatal output during early postnatal development affects the activity and maturation of the dorsomedial prefrontal cortex circuits in mice.

Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B-/- Mice

This study identifies early dysfunction in ACC PV interneurons and HCN channelopathy in Shank3B-/- mice, leading to circuit reorganization and impaired inhibition.

Late onset of striatal projection neuron hyperexcitability in Fmr1-/y mice

This study shows that striatal projection neurons in Fmr1 knockout mice develop normally but become hyperexcitable by postnatal day 60, with limited response to aripiprazole treatment.

Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B-/- mice

This study investigates synaptic deficits in cortical PV interneurons of Shank3B-/- mice, finding reduced mEPSC frequency in adulthood but not early development, and region-specific differences.