Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
Yi-Heng Tai, Daniel Engels, Giuseppe Locatelli, Ioanna Emmanouilidis, Caroline Fecher, Delphine Theodorou, Stephan A. Müller, Simon Licht‐Mayer, Mario Kreutzfeldt, Ingrid Wagner, Natália Prudente de Mello, Sofia-Natsouko Gkotzamani, Laura Trovò, Arek Kendirli, Almir Aljović, , Thomas Misgeld
The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.
Nature Metabolism · Jul 10, 2023Peer-reviewedNeuroscience