Arek Kendirli

This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.

This paper introduces a FACS-based preprocessing workflow for PBMCs that improves scRNA-seq throughput and preserves biological integrity while enabling rare cell enrichment and cross-donor multiplexing.

The paper identifies RORγt-expressing dendritic cells as a distinct APC lineage conserved across tissues and species, with functions beyond promoting tolerance.

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.