Fabiana Perocchi

MCUR1-CCDC90B complex is a conserved mitochondrial scaffold regulating metabolic homeostasis

This study identifies the MCUR1-CCDC90B complex as a mitochondrial scaffold regulating metabolic homeostasis, showing its role in amino acid metabolism and linking its deficiency to neurometabolic disease.

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.

Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations

mitoXplorer is a web-based platform that integrates and visualizes mitochondrial gene expression and mutation data across multiple datasets to uncover regulatory differences in mitochondrial dynamics.

MICU1 modulates MCU ion selectivity and tolerance to manganese stress

This study shows MICU1 is essential for MCU ion selectivity and protects cells from manganese toxicity.