CNOT1 mediates phosphorylation via Protein kinase A on the circadian clock
Yun Feng Zhang, Haitang Qin, Yongjie Feng, Peng Gao, Yingbin Zhong, Yicheng Tan, Han Wang, Ying Xu, Joseph S. Takahashi, Guocun Huang
This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.
bioRxiv · May 8, 2019 · PreprintDevelopmental Biology