Peng Gao

Complete genome-derived metabolic interactions reveal impact of gut ecology on human health

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

Complete Genomes of Cultivated Gut Bacteria Reveal Mobile Genetic Element-Driven Functional Diversity with Therapeutic Implications

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

A new subgenome of the Camelina genus reveals genome dominance is controlled by chromosomal proximity

The paper reports new genome assemblies of Camelina species, revealing subgenome dominance patterns linked to chromosomal proximity and structure in polyploid evolution.

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

TaWUS2D regulates the number of grains per spikelet by enhancing the number of fertile ovaries in Multi-Ovary Wheat

This study identifies TaWUS2D as a gene that increases grain number per spikelet by promoting fertile ovaries in wheat through genetic and genomic analyses.

Hybrid diffuse optical monitoring of hemodynamic changes following acute cerebral ischemia in a porcine model

This paper demonstrates that hybrid diffuse optical measurements can detect hemodynamic changes in cerebral ischemia within hours in a porcine model, with BFI as a potential biomarker.

CNOT1 mediates phosphorylation via Protein kinase A on the circadian clock

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.