Han Wang

This study investigates the role of circadian clock genes in kidney regeneration using zebrafish, finding that per1 and nr1d1 promote regeneration by repressing lima1a, which regulates EMT.

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.

This paper generates zebrafish models for human ALA-dehydratase-deficient porphyria and hereditary coproporphyria using TALEN and CRISPR-Cas9, revealing phenotypes similar to human diseases.