Testing the plasticity-first theory of tumor evolution with spatiotemporal lineage tracing
Jinhua Yang, Liangzhen Hou, Xue Wang, Ningxia Zhang, Yifei Bian, Zhaolian Lu, Yanxu Chen, Duo Xie, Yongting Fang, Kun Wang, Ruijie Wan, Yujuan Jin, Yuan Chen, Xinlei Cai, Xiaojing Hu, , Herrero-Herrero Ji
This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.
bioRxiv · Aug 6, 2025 · PreprintCancer Biology