Arginine Metabolism Supports De Novo Pyrimidine Biosynthesis to Block DNA Damage and Maintain Epstein-Barr Virus Latency
Shaowen White, Yifei Liao, Yin Wang, Shunji Li, Eric M. Burton, John M. Asara, Benjamin E. Gewurz
This study identifies arginine metabolism as critical for maintaining Epstein-Barr virus latency by supporting de novo pyrimidine biosynthesis, and shows that restricting arginine or disrupting pyrimidine synthesis can induce EBV reactivation.
mBio · Jun 15, 2026Peer-reviewedMicrobiology