John M. Asara

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

The paper identifies protein interactors of COPD GWAS genes using AP-MS and network analysis, revealing a disease network module involving 8 proteins.

This study shows that methionine restriction induces ferroptosis in EBV-transformed B cells by promoting transsulfuration and glutathione synthesis, and that targeting methionine metabolism can impair tumor growth.

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

This study identifies arginine metabolism as critical for maintaining Epstein-Barr virus latency by supporting de novo pyrimidine biosynthesis, and shows that restricting arginine or disrupting pyrimidine synthesis can induce EBV reactivation.

This study maps central carbon metabolism in Hippo-Yki-driven Drosophila gut tumors, revealing conserved metabolic principles shared with mammalian cancer metabolism.

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

This study shows that EBV's LMP1 protein prevents ferroptosis by enhancing glutathione and NADPH through the pentose phosphate pathway and cystine uptake.

This study shows that Trr1 depletion in C. albicans increases sensitivity to antifungals and cell wall stress by disrupting metabolic pathways and cell wall synthesis.

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

The paper identifies Zrf1 as an epigenetic factor regulating intestinal stem cell proliferation and genome stability in Drosophila midgut regeneration.

The paper identifies a cytokine-lipid axis that links systemic inflammation to hepatic autophagy dysfunction in cancer across species.

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

This study identifies LMP1-driven metabolic reprogramming in B-cells, showing that IMPDH inhibition sensitizes EBV-transformed cells to apoptosis, suggesting therapeutic targets for LMP1-driven lymphomas.

The paper identifies HHIP protein interactions in lung cells, revealing new connections to COPD GWAS genes and providing insights into COPD pathogenesis.

The paper identifies and validates tyrosine phosphorylation sites on metabolic enzymes using parallel phosphoproteomics and metabolomics in MCF10A cells.

This study shows that methylmalonic acid impairs CD8+ T cell function and promotes tumor growth by inducing metabolic dysfunction and exhaustion.

This study builds tissue-specific metabolic models for Drosophila to identify metabolic dysregulation in muscle caused by a high sugar diet.

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.