Shaowen White

This study uses a genome-wide CRISPR-Cas9 screen to identify host factors essential for EBV B cell infection, revealing new pathways and potential therapeutic targets.

This study shows that methionine restriction induces ferroptosis in EBV-transformed B cells by promoting transsulfuration and glutathione synthesis, and that targeting methionine metabolism can impair tumor growth.

This study identifies arginine metabolism as critical for maintaining Epstein-Barr virus latency by supporting de novo pyrimidine biosynthesis, and shows that restricting arginine or disrupting pyrimidine synthesis can induce EBV reactivation.

This study identifies LMP1-driven metabolic reprogramming in B-cells, showing that IMPDH inhibition sensitizes EBV-transformed cells to apoptosis, suggesting therapeutic targets for LMP1-driven lymphomas.