Butyrate Rescues Cardiac Metabolic Dysfunction in Hypertensive Heart Failure with Preserved Ejection Fraction
Sarah M. Kedziora, Sabrina Y. Geisberger, Oliver Popp, Alina Frovola, Alisa Uhrbach, Kristin Kräker, Nurana Tagiyeva, Marcus Kelm, Nikolaus Berndt, Yiming D. Zhang, Guido Mastrobuoni, Raquel Escrihuela-Branz, Theda U. P. Bartolomaeus, Lorenz Pixner, Pauline Fahjen, , Nadine Haase
This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.
bioRxiv · Nov 28, 2025 · PreprintBiochemistry