Dominik N. Müller

This study identifies a microbiome-AhR-IL-17A axis that drives CKD-associated cardiac fibrosis and shows that AhR inhibition prevents remodeling.

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

The paper shows that T cells from treatment-resistant hypertension patients worsen hypertension and endothelial dysfunction in humanized mice through TNF.

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

This study shows maternal smoking disrupts placental function by altering syncytiotrophoblast and macrophage biology, leading to fetal growth restriction.

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

This study investigates how baseline gut microbiome composition affects resilience to and recovery from antibiotic treatment, identifying key taxa and functional modules associated with resilience.

The paper identifies a disrupted trophoblast transition in preeclampsia, linking placental pathology to maternal syndrome through multi-omics profiling and in vitro analyses.