Complete elucidation and heterologous reconstruction of the biosynthetic pathway of camptothecin
Tong Zhang, Ying Xiong, Kuangqin Chen, Shiwen Wu, Xing Yan, Jie Zhou, Yan Wang, Chengshuai Yang, Pingping Wang, Zhihua Zhou
This study identifies the complete biosynthetic pathway of camptothecin, discovers missing enzymes, and validates the pathway through heterologous reconstruction in yeast.
bioRxiv · Jun 25, 2026 · PreprintSynthetic Biology