Ying Xiong

This paper develops two hybrid calcium indicators, HyBRIC and HyBRIC2, that use luciferase activation and BRET for high-contrast red-window calcium imaging with improved brightness and responsiveness.

This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.

This study identifies two novel genomic loci associated with antidepressant non-response and suggests potential drugs for further validation.

This paper develops a bioluminescent calcium indicator and prosubstrate for non-invasive imaging of neuronal activity in awake mice.