The Alexander Disease Protein GFAP Drives Mitochondrial Fission
Ding Xiong, Ye Sing Tan, Yuan Fang, Yinglu Li, Kay En Low, Isabelle Bonne, Sakthikumar Mathivanan, Phil Jun Kang, Zijun Sun, Xueyan Li, Emily Abella, Albee Messing, Linghai Kong, Su‐Chun Zhang
This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.
Proceedings of the National Academy of Sciences · Nov 26, 2025Peer-reviewedCell Biology