Ye Sing Tan

Loss of IVNS1ABP, a gigaxonin paralogue, leads to a progeroid neuropathy due to impaired proteostasis

This study shows that loss of IVNS1ABP causes a progeroid neuropathy by impairing proteostasis, leading to protein aggregation and lysosomal dysfunction in neuronal cells.

Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling

This study identifies a GPCR signaling pathway in astrocytes that regulates F-actin remodeling and NSC reactivation through Mrtf nuclear translocation.

Arl2 Associates with Cdk5rap2 to Regulate Cortical Development via Microtubule Organization

This study shows that Arl2 regulates mouse cortical development by promoting microtubule growth through its interaction with Cdk5rap2.

Msps Governs Acentrosomal Microtubule Assembly and Reactivation of Quiescent Neural Stem Cells

This study identifies Msps/XMAP215 as a regulator of acentrosomal microtubule assembly in quiescent Drosophila NSCs, which is essential for E-cadherin localization and NSC reactivation.

Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells

This study shows that Parafibromin/Hyrax regulates cell polarity and centrosome assembly in neural stem cells, preventing overgrowth and tumour formation.