Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
W. James Gauderman, Yubo Fu, Bryan Queme, Eric S. Kawaguchi, Yinqiao Wang, John L. Morrison, Hermann Brenner, Andrew Tan Chan, Stephen B. Gruber, Temitope O. Keku, Li Li, Victor Rau Moreno, Andrew Jared Pellatt, Ulrike Peters, Niloy Jewel Samadder, , Huaiyu Mi
The paper introduces pathway-based polygenic risk scores (pPRS) to detect gene-environment interactions, finding a significant interaction between NSAIDs and the TGF-β/GRHR pathway in colorectal cancer.
bioRxiv · Dec 16, 2024 · PreprintGenetics