Restoration of MAIT cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria
Yiting Xue, Asad Mustafa Karim, Wan Rong Sia, Fei Han, Kian Sing Chan, Nathalie Grace Sy Chua, Leila Hadadi, Zhenyu Liu, Jeffrey Y. W. Mak, David P. Fairlie, Lin‐Fa Wang, Johan K. Sandberg, Andrea Lay‐Hoon Kwa, Edwin Leeansyah
This study shows that stimulating MAIT cells with specific cytokines enhances their antibacterial activity and restores carbapenem efficacy against resistant bacteria in patients with healthcare-associated infections.
bioRxiv · Nov 21, 2025 · PreprintImmunology