Jeffrey Y. W. Mak

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

This study examines how MAIT cells respond to S. aureus and how their sensitivity to the toxin HlgAB varies by tissue location and activation state.

This study shows that stimulating MAIT cells with specific cytokines enhances their antibacterial activity and restores carbapenem efficacy against resistant bacteria in patients with healthcare-associated infections.

This study shows that purinergic signaling via ARTC2 and P2RX7 regulates the survival and function of unconventional T cells, affecting IFN-γ and IL-4 production.