Author

Yoav Shamir

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Adi RogeliD· 2 shared Nir LondoniD· 2 shared Ronen GabizoniD· 2 shared Almog Nadir· 1 shared Amy Hamilton AndreottiiD· 1 shared Atar GilatiD· 1 shared Barr Tivon· 1 shared David Margulies· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Adi RogelORCID

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2 papers

Recent·Most cited

Discovery of novel covalent ligands with AlphaFold3

Yoav Shamir, Ronen Gabizon, Adi Rogel, David Yin-wei Lin, Amy Hamilton Andreotti, Nir London

This study demonstrates that AlphaFold3 can effectively discover novel covalent inhibitors for kinases through virtual screening, outperforming existing methods and validating predictions with co-crystallography.

Journal of the American Chemical Society · Mar 20, 2026Peer-reviewedBiochemistry

A pharmacological modality to sequester homomeric proteins

Ella Livnah, Ohad Suss, Adi Rogel, Atar Gilat, Yuval Abdan, José A. Villegas, Ronen Gabizon, Almog Nadir, Yoav Shamir, Noam Y. Steinman, Barr Tivon, Shira Albeck, Tamar Unger, Ofra Golani, Inna Goliand, , Nir London

This paper introduces PINCHs, bifunctional molecules that sequester homomeric proteins by inducing polymerization, demonstrating efficacy in knocking down protein function in cells.

Nature Chemical Biology · Feb 5, 2026Peer-reviewedBiochemistry