Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

Nature · Apr 15, 2026Peer-reviewedCell Biology✦ In-depth digest

A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid

Yael Korem Kohanim, Tal Barkai, Roy Novoselsky, Sapir Shir, Keren Bahar Halpern, Shlomit Reich-Zeliger, Jacob Elkahal, Idit Tessler, Shaked Shivatzki, Ignat Schwartz, Eric Remer, Galit Avior, Rouven Hoefflin, Merav Kedmi, Hadas Keren‐Shaul, , Ruslan M. Medzhitov

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

bioRxiv · Mar 16, 2026 · PreprintSystems Biology

Spatial analysis reveals the evolving organization of low-grade and high-grade IDH-mutant glioma

Rouven Hoefflin, Alissa Greenwald, Noam Galili Darnell, Christopher Mount, Yali Tiomkin, Dor Simkin, Angelica Brooke Patterson, L. Nicolas Gonzalez Castro, Inna Goliand, Ofra Golani, Kevin Joseph, Jürgen Beck, Vidhya Madapusi Ravi, Merav Kedmi, Hadas Keren‐Shaul, , Itay Tirosh

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

bioRxiv · Mar 13, 2026 · PreprintCancer Biology

Spatial Rewiring of Enterocyte Identity in Celiac Disease

Tal Barkai, Rachel Frieman-Sharabi, Keren Bahar Halpern, Roy Novoselsky, Yael Korem Kohanim, Sapir Shir, Ofra Golani, Inna Goliand, Yoseph Addadi, Merav Kedmi, Hadas Keren‐Shaul, Lena Prichislov, Anat Guz‐Mark, Hadassah Nissim, R Shamir, , Shalev Itzkovitz

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

bioRxiv · Feb 17, 2026 · PreprintSystems Biology

A pharmacological modality to sequester homomeric proteins

Ella Livnah, Ohad Suss, Adi Rogel, Atar Gilat, Yuval Abdan, José A. Villegas, Ronen Gabizon, Almog Nadir, Yoav Shamir, Noam Y. Steinman, Barr Tivon, Shira Albeck, Tamar Unger, Ofra Golani, Inna Goliand, , Nir London

This paper introduces PINCHs, bifunctional molecules that sequester homomeric proteins by inducing polymerization, demonstrating efficacy in knocking down protein function in cells.

Nature Chemical Biology · Feb 5, 2026Peer-reviewedBiochemistry

TECPR2 maintains mitochondrial homeostasis in neurodegeneration

Madhuri Chaurasia, Milana Fraiberg, Nemanja Subic, Oren Shatz, Kamilya Kokabi, Olee Gogoi, Olena Trofimyuk, Bat Chen Tamim-Yecheskel, Saskia Freud, Alik Demishtein, Ekaterina Kopitman, Inna Goliand, Sabita Chourasia, Yoav Peleg, Elena Ainbinder, , Zvulun Elazar

This study shows that TECPR2 loss causes mitochondrial dysfunction and mitophagy impairment in HSAN9, which can be mitigated by ISR suppression.

bioRxiv · Sep 4, 2025 · PreprintCell Biology

Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning

Raz Ben-Uri, Lior Ben Shabat, Dana Shainshein, Omer Bar-Tal, Yuval Bussi, Noa Maimon, Tal Keidar Haran, Idan Milo, Inna Goliand, Yoseph Addadi, Tomer‐Meir Salame, Alexander Rochwarger, Christian M. Schürch, Shai Bagon, Ofer Elhanani, Leeat Keren

This paper introduces CombPlex, a combinatorial staining method combined with deep learning to measure more proteins at single-cell resolution without needing specialized imaging equipment.

bioRxiv · Sep 9, 2023 · PreprintSystems Biology