Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast
Yojiro Hoshikawa, Natsuho Shirota, Hiroshi Tsugawa, Satoshi Kimura, Akihisa Matsuyama, Yoko Yashiroda, Hideaki Kakeya, Makoto Arita, Reiko Cullum, Minoru Yoshida, Shinichi Nishimura
This study shows that pentadecanoic acid causes lipotoxicity in fission yeast by forming giant ER sheets, disrupting cell division.
Proceedings of the National Academy of Sciences · May 27, 2025Peer-reviewedCell Biology