Makoto Arita

Host-Derived Lipids Sustain Membrane Biogenesis in an Obligate Endosymbiont

The paper investigates how host-derived lipids sustain membrane biogenesis in the obligate endosymbiont Buchnera aphidicola, showing host lipid metabolism is critical for symbiont survival.

Elucidation of the anti-inflammatory mechanism of isoliquiritigenin from Glycyrrhiza uralensis using activity-based protein profiling

This study identifies L-PGDS as a covalent target of isoliquiritigenin, revealing its anti-inflammatory mechanism through suppression of PGD2 production.

Dual Metabolic Compensation to Dietary Choline Deficiency by the Drosophila Hologenome

This study identifies two mechanisms by which Drosophila compensates for choline deficiency: a bacterial PC synthesis pathway and host-derived βmPC production from carnitine.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast

This study shows that pentadecanoic acid causes lipotoxicity in fission yeast by forming giant ER sheets, disrupting cell division.

Data-independent acquisition coupled with electron-activated dissociation for in-depth structure elucidation of fatty acid ester of hydroxy fatty acids

This study develops a LC-SWATH-EAD-MS/MS method to deeply characterize FAHFAs in mouse fecal samples, identifying multiple structural variants and age-related changes.

MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

The paper introduces MS-DIAL 5, a tool for analyzing multimodal mass spectrometry data to elucidate lipid structures and localization using structural annotations.

MS2Lipid: a lipid subclass prediction program using machine learning and curated tandem mass spectral data

MS2Lipid predicts lipid subclasses from MS/MS data using machine learning, achieving high accuracy and outperforming existing tools.

One thousand samples per day capillary-flow LC/MS/MS for high-speed, high-sensitivity and in-depth proteomics

This paper develops a high-speed LC/MS/MS system achieving 1,000 samples per day with high sensitivity and depth, demonstrating its application in spatial proteomics of mouse brain.

MS-DIAL 4: accelerating lipidomics using an MS/MS, CCS, and retention time atlas

MS-DIAL 4 provides a comprehensive lipidome atlas with retention time, collision cross section, and MS/MS data to standardize and accelerate lipidomics research.

Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.