Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation
Simeng Li, Siman Shen, Yongfang Hong, Kun Ding, Suyun Chen, Jianning Chen, Changsen Wang, Yaofeng Wen, Guixi Mo, Lili Yu, De‐Li Shi, Liangqing Zhang
This study shows that Sirt5 protects against cardiac ischemia-reperfusion injury by inhibiting ANT2 lactylation, which enhances its interaction with VDAC1 and preserves mitochondrial function.
Cellular and Molecular Life Sciences · Jul 28, 2026Peer-reviewedPathology