APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids
Karina K. Meyer-Acosta, Eva Díaz‐Guerra, Parul Varma, Adyasha Aruk, Sara Mirsadeghi, Aranis Muniz Perez, Yousef Rafati, Ali Hosseini, Vanesa Nieto‐Estévez, Michèle Giugliano, Christopher S. Navara, Jenny Hsieh
This study shows APOE4 affects cortical neurodevelopment and network formation in human brain organoids by altering cell types, increasing cell death, and disrupting GABA signaling.
Stem Cell Reports · Jun 19, 2025Peer-reviewedNeuroscience