Neuronal Toll-like Receptor-4 regulation of Matrix Metalloproteinase-9 Activity Mediates Dentate Circuit Dysfunction after Traumatic Brain Injury
Deepak Subramanian, Erick M. Contreras, Laura Dovek, Razieh Jaberi, Emmanuel Green, Ysabelle K Lao, Iryna M. Ethell, Vijayalakshmi Santhakumar
This study identifies a TLR4-MMP-9 signaling axis that drives early post-TBI dentate gyrus circuit dysfunction and behavioral deficits in rodents.
Journal of Neuroinflammation · Jun 3, 2026Peer-reviewedNeuroscience