Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells
Nghia Trong Nguyen, Yu Min, Jennifer Rivière, Mark van der Garde, Sukhen C. Ghosh, Laura M. Bartos, Matthias Brendel, Florian C. Bassermann, Ali Azhdarinia, Wolfgang Weber, Katharina S. S. Götze, Susanne Kossatz
This paper shows that hematopoietic stem and progenitor cells express somatostatin receptors, leading to unexpected toxicity from radiopharmaceuticals used in neuroendocrine tumors.
Theranostics · May 25, 2025Peer-reviewedCancer Biology