Author

Yuan Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Bo HuangiD· 1 shared H Z WangiD· 1 shared Hanshuo LuiD· 1 shared Hongbo ZhangiD· 1 shared Q ZhouiD· 1 shared Qingbo Xu· 1 shared Ruoyao Ran· 1 shared Shaole Chang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Bo HuangORCID

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2 papers

Recent·Most cited

CellOS: Learning a World Model of Cellular State through Joint Embedding Prediction

Q Zhou, Yuan Le, Xiaoning Qi, Hanshuo Lu, Shaole Chang, Yujia Wu, H Z Wang, Ruoyao Ran, X F Li

CellOS is a multi-view foundation model trained on single-cell transcriptomes that outperforms existing models in cell-state annotation, batch integration, and perturbation-response prediction.

bioRxiv · Jun 25, 2026 · PreprintBioinformatics

Using macromolecular electron densities to improve the enrichment of active compounds in virtual screening

Wenzhi Ma, Wei Zhang, Yuan Le, Xiaoxuan Shi, Qingbo Xu, Xiao Ping Yang, Yueying Dou, Xiaoman Wang, Wenbiao Zhou, Wei Peng, Hongbo Zhang, Bo Huang

This paper introduces ExptGMS, a method using experimental electron density data to improve virtual screening by enhancing active compound enrichment, achieving a 20% improvement and identifying new inhibitors.

Communications Chemistry · Aug 22, 2023Peer-reviewedBioinformatics