X F Li

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

The paper shows that annual life-history strategy in seagrass is linked to low-light adaptation through genetic coupling of SAPK7 and CAO genes.

CellOS is a multi-view foundation model trained on single-cell transcriptomes that outperforms existing models in cell-state annotation, batch integration, and perturbation-response prediction.

This study evaluates clinically relevant vaccine adjuvants using a human immune organoid model, identifying AddaSO3 as consistently effective across early and prolonged immune response phases.

SpaCir-VDJ enables spatial immune repertoire profiling by integrating spatial barcodes and V(D)J sequences into circular templates, revealing clonal organization and somatic hypermutation patterns in human tissues and gastric cancer.