Extracellular vesicles released from endothelial cells of the blood-brain barrier mediate brain Iron accumulation during LPS-induced brain Inflammation
Kondaiah Palsa, Timothy B. Helmuth, Aurosman Pappus Sahu, Yuanjun Zhao, Rebecka O. Serpa, Elizabeth B. Neely, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor
This study shows that brain inflammation increases iron accumulation in brain tissue via extracellular vesicles (EVs) released from blood-brain barrier endothelial cells, and inhibiting EVs reduces iron accumulation.
Journal of Biological Chemistry · Mar 21, 2026Peer-reviewedNeuroscience