Author

Timothy B. Helmuth

Pennsylvania State UniversityORCID 0000-0002-7002-5997Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Elizabeth B. NeelyiD· 2 shared James R. ConnoriD· 2 shared Kondaiah PalsaiD· 2 shared Angela Baker· 1 shared Aurosman Pappus SahuiD· 1 shared Aurosman Sahu· 1 shared Becky Slagle‐WebbiD· 1 shared Ganesh ShenoyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Elizabeth B. NeelyORCID

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2 papers

Recent·Most cited

Iron-deficiency in the tumor microenvironment reprograms tumor-immune interactions in a sex biased manner

Aurosman Sahu, Yue Hao, Angela Baker, Kondaiah Palsa, Timothy B. Helmuth, Ganesh Shenoy, Elizabeth B. Neely, Becky Slagle‐Webb, Michael E. Berens, J F Connor

This study shows that iron deficiency in glioblastoma tumors affects immune interactions differently in males and females.

bioRxiv · Jun 2, 2026 · PreprintCancer Biology

Extracellular vesicles released from endothelial cells of the blood-brain barrier mediate brain Iron accumulation during LPS-induced brain Inflammation

Kondaiah Palsa, Timothy B. Helmuth, Aurosman Pappus Sahu, Yuanjun Zhao, Rebecka O. Serpa, Elizabeth B. Neely, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor

This study shows that brain inflammation increases iron accumulation in brain tissue via extracellular vesicles (EVs) released from blood-brain barrier endothelial cells, and inhibiting EVs reduces iron accumulation.

Journal of Biological Chemistry · Mar 21, 2026Peer-reviewedNeuroscience