Author

Irina A. Elcheva

Pennsylvania State UniversityORCID 0000-0002-3992-2817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Ahsan PolashiD· 1 shared Alexis MorrisseyiD· 1 shared Arati Sharma· 1 shared Aurosman Pappus SahuiD· 1 shared ChaeMin KimiD· 1 shared Cheryl A. KelleriD· 1 shared Edward Harhaj· 1 shared Elizabeth A. ProctoriD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Ahsan PolashORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 29, 2026

Oncofetal RNA-binding proteins of IGF2BP family suppress IRF-3 and NF-kB dependent transcription downstream of cytosolic RNA sensors

Garrett Knox, Ruba Agili-Shaban, Alexis Morrissey…·Irina A. Elcheva

This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.

DOI 10.64898/2026.05.22.726816

humanbulk RNA-seq

NeuroscienceJournal of Biological ChemistryPeer-reviewedMar 21, 2026

Extracellular vesicles released from endothelial cells of the blood-brain barrier mediate brain Iron accumulation during LPS-induced brain Inflammation

Kondaiah Palsa, Timothy B. Helmuth, Aurosman Pappus Sahu…·James R. Connor

This study shows that brain inflammation increases iron accumulation in brain tissue via extracellular vesicles (EVs) released from blood-brain barrier endothelial cells, and inhibiting EVs reduces iron accumulation.

1 citation

mouseexperimental assay

NeurosciencebioRxivPreprintNov 16, 2023

Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids

Madison K. Kuhn, Rachel Y. Kang, ChaeMin Kim…·Elizabeth A. Proctor

This study uses AD organoids to identify dynamic neuroinflammatory profiles and their impact on neuronal health and microglial function.

8 citations

humanbulk RNA-seq