Vladimir S. Spiegelman

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

This study shows that brain inflammation increases iron accumulation in brain tissue via extracellular vesicles (EVs) released from blood-brain barrier endothelial cells, and inhibiting EVs reduces iron accumulation.

AVJ16 inhibits IGF2BP1 in lung adenocarcinoma cells and xenografts, reducing proliferation, enhancing apoptosis, and preventing tumor growth.

This study identifies Ikaros and HDAC1's roles in regulating heterochromatin and tumor suppression in T-ALL by modulating EZH2 activity and chromatin structure.

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

The paper introduces exclusion-based immunoprecipitation methods to identify RNA binding partners of CRD-BP in mammary epithelial cells, showing enrichment in mRNAs related to mitochondrial function and oxidative stress.