Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus MT:10398A>G
Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel Barton, Jivanna N. Mason, Yucheng Zhang, Aria Fernandez-Fontaine, George McDonald Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin P. Readhead
The paper investigates the association between mitochondrial variant MT:10398A>G and heteroplasmy in brain tissue and lymphoblastoid cell lines, identifying its role in mitochondrial function and disease phenotypes.
Scientific Reports · Jun 27, 2023Peer-reviewedGenomics