Diego Mastroeni

The paper provides a public resource of single nucleus RNA sequencing data and multiscale networks from Alzheimer's disease and non-disease individuals, linking genetic variants to molecular features and revealing novel disease biology.

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

The paper identifies the nucleus incertus (NI) in humans using neurochemical markers and shows its RLN3 expression and potential involvement in Alzheimer's disease pathology.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

The paper finds reduced PIN1 gene expression in female Alzheimer's patients correlates with cognitive decline and neuropathological features, suggesting it as a potential biomarker for AD risk in women.

The paper investigates the association between mitochondrial variant MT:10398A>G and heteroplasmy in brain tissue and lymphoblastoid cell lines, identifying its role in mitochondrial function and disease phenotypes.

This study investigates the long-term cognitive and cerebrovascular effects of mild traumatic brain injury in rats, finding chronic cognitive dysfunction and altered vascular reactivity.

This study uses quantitative phosphoproteomics to identify dysregulated kinase networks associated with Alzheimer's disease histopathologies.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

The paper uses phosphoproteomics to identify Siglec-F and Siglec-8 as upregulated in microglia during neurodegeneration, driving inflammatory responses in mouse and human models.

This paper introduces a highly sensitive in situ proteomics method using cleavable fluorescent tyramide and antibodies, enabling detailed analysis of protein expression in human tissues.

This paper introduces a method for highly sensitive and multiplexed in situ protein profiling using cleavable fluorescent streptavidin and biotin conjugated antibodies, achieving 10-fold improved sensitivity over existing methods.