Coronavirus NSP14 Drives Internal m7G Modification to Rewire Host Splicing and Promote Viral Replication
Ensueño Esmeralda Sáenz Altamirano, Chien-Hsin Huang, Yueh-Lin Tsai, Tiffany J. Tzeng, Natália Teruel, Yoatzin Peñaflor-Téllez, Shruti Chatterjee, Isha Pandey, Neelam Oswal, Y. Grace Chen, Ching‐Wen Chang, Ricardo Rajsbaum, Lok-Yin Roy Wong, Ivan Reis Correa Junior, Jack Chun-Chieh Hsu
This study identifies NSP14's role in inducing internal m7G modification in host mRNA, disrupting splicing and promoting SARS-CoV-2 replication, with implications for therapeutic targeting.
Nucleic Acids Research · Aug 8, 2026Peer-reviewedMicrobiology