Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes
Xiaoyun Ding, Yuki Ogawa, Victoria L. Palfini, Wei Zhang, Andrew P. Anderson, Lucia Lucia Gancedo-Lopez, Zian Liao, Zihan Yang, Seth G. Haddix, Yueheng Xing, Duc Nguyen, Jackson R. Curtis, Davis Church, Yu Wu, Antrix Jain, , Matthew Neil Rasband
This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.
bioRxiv · Aug 23, 2026 · PreprintNeuroscience